What can I use with The Ordinary Argireline Solution 10%

[anastasiiia]

I’m interested in purchasing 

The OrdinaryArgireline Solution 10% but I’m not sure what I can/cannot use with this product. Help! The Ordinary Argireline Solution 10% Serum for Facial Wrinkles 1 oz/ 30 mL  

[Saradestin]

Hi @anastasiiia! I have been using my The Ordinary Argireline for several years and I LOVE it! It has done wonders for my wrinkles. I use it morning and night only on wrinkles and as a first step. I have been using it with all sorts of serums and I haven’t had any issues. I just try to avoid mixing with Vitamin C because it may affect the peptide efficacy but I have used them together several times with no adverse reaction.

[WinglessOne]

@anastasiiia  You can use pretty much anything with that product, since it's basically a peptides serum. Off the top of my head, I don't know of anything that doesn't play nice with argireline. 

Note that The Ordinary claims you shouldn't use peptides in general with ascorbic acid (vitamin C's pure form); they list this conflict at their own site for their argireline serum. I think that's a very wide blanket statement they make so they won't have to get super specific about which of their products conflict with one another. But it's not a very accurate statement: vitamin C and its derivatives can work fine with various peptides. 

[CynthieLu]

I heard the whole Peptides vs Vitamin C is that, in specific clinical trials it was proven it could theoretically cause a reaction but that it's not very likely? I say tread with caution? Maybe if you do mix it try it somewhere inconspicuous like your inner arm or something before your face? 

[CynthieLu]

I heard these studies referenced to but I don't actually know I'm sorry to say.  One blogger, Cassandra Bankson, mentions it in a few of her vids that the studies that show the vitamin c reaction to products, claiming that the conditions used in the test do not mimic what world occur in the actual world. 

But that being said mixing known ingredients that don't mesh is not a good idea, but when it comes to vitamin C that one is possibly worth researching furthur

[WinglessOne]

@CynthieLu  Hmm, I wonder which specific peptide(s) the trials studied, which form of vitamin C (I assume it was ascorbic acid) was used, and how both ingredients were applied/introduced (hopefully topically, not orally or via injection)... now I'll have to try hunting down those studies. If the results are theoretical, then they're not proven. 

It's always a good idea to patch test new products, though, especially if you have sensitive or reactive skin. Peptides aren't infamously dangerous—they're good hydrators and theoretically (heh, there's that word again) convince skin cells to behave in specific ways, depending on the peptide—but anyone can be sensitive to nearly anything, including vitamin C. So yes, when in doubt, patch test first.