Honestly, if money is no object, Perricone is kind of the gold standard for anti-aging from a scientific standpoint. He even funds research on ingredients like alpha lipoic acid to find out what actually works. To say this is rare in the industry is to put it mildly. Another science based line is Obagi Clinical, which uses the patented ingredient kinetin that has been clinically proven to slow aging. If you're looking for serious anti-aging you're probably old enough to remember the brand Kinerase which was around in the late 90's and hyped a lot by dermatologists with Courtney Cox in their ads. It was expensive, I never tried it, but I sure saw ads everywhere. Kinetin was their baby, but the company got tired of making it, now Obagi Clinical uses the patent, as do some of the Estee Lauder lines. Don't count Estee Lauder out, they have several anti-aging lines, though they tend to be highly fragranced and pretty hazy about their ingredient lists claiming trade secrets. But they are elegant and easy to find in department stores. Other lines tend to focus on a single ingredient they use marketing buzzwords to create a sense of magic around. Ginseng is popular and does contain saponins, an antioxidant (Sulwhasoo), tea or green tea extracts, which contain catechins, another antioxidant (AmorePacific), l'Occitane has helichrysum oil, which is a flower, La Mer has its mystery algae extract, Lancer has hylaplex, Algenist has a different magic algae which has never done anything for me, Guerlain uses honey or an orchid depending on the line, la Prairie has caviar extract, for whatever reason, combined with some amino acids, SK-II has saccharomyces, a probiotic ferment that is actually an industrial waste product of sake making that they call pitera and pretend they aren't selling a common ingredient worth pennies for hundreds of dollars, it's all a huge scam. Go to lotioncrafters dot com and see for yourself how cheap these magic ingredients are. All of which is to say that only two ingredients have been clinically proven to slow aging: retinoids (prescription, Retin-A, tretinoin is the generic) and their lesser retinol derivatives, and kinetin. Most luxury brands simply charge outrageous amounts of money for retinol, which is just as good when you buy it from Neutrogena. Other ingredients like alpha lipoic acid have been shown to have observable effects on wrinkles (thioctic acid in ingredient lists), and are available super cheap as over the counter supplements. The rest are some peptides with topical Botox- like effects, and of course antioxidants, which are all kinds of good for you but mostly address uv exposure, and are no replacement for sunblock. While most products put a single antioxidant in each product, a better option is a big fat antioxidant cocktail from an extremely science forward brand called Skin Actives. Their UV Repair Cream took ten years off my extremely pampered face, which I didn't think could be done. Check them out, I have loved everything I've gotten from them except their all-zinc sunscreen because even I'm not that pale! But the TL;DR of it is go to a dermatologist and get Retin-A. It works, there's proof. Then get an antioxidant 0rgy from either Skin Actives or Perricone, and buy whatever else your skin likes. Moisture matters, but Hyaluronic acid serums that cost more than$7 are robbery, get the one from The Ordinary. Bobbi Brown's cream is lovely, so are Obagi Clinical and Perricone's classic firming cream, but skip Peter Thomas Roth entirely, I know a cosmetic chemist who can explain why every PTR product is good ingredients thrown in the garbage, everything at the wrong pH. And find a sunblock you love and use it like a religion.